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The effect of four weeks of incremental endurance training on sarcolipin, FNDC5 and PGC1α proteins in Soleus and extensor digitorum longus of male Wistar rats | ||
| پژوهشنامه فیزیولوژی ورزشی کاربردی | ||
| Article 9, Volume 17, Issue 34, December 2021, Pages 141-151 PDF (852.3 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.22080/jaep.2022.22367.2069 | ||
| Authors | ||
| Moein Fasihiyan1; Fariba Khodagholi2; Maryam Nourshahi* 1 | ||
| 1Department of Sport Physiology, Faculty of Sport Sciences, Shahid Beheshti University, Tehran, Iran | ||
| 2Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
| Receive Date: 25 September 2021, Revise Date: 15 December 2021, Accept Date: 07 March 2022 | ||
| Abstract | ||
| Background & Purpose: The aim of this study was to determine the effect of four weeks of incremental endurance training on Sarcolipin (SLN), FNDC5, and PGC1α protein levels in the soleus (SOL) and extensor digitorum longus (EDL) muscle of adult male Wistar rats. Methodology: In this experimental study, 14 adult male Wistar rats were divided into two groups of control (n=7) and training (n=7). The training group performed endurance exercises for 4 weeks and 5 sessions per week, which included running at the intensity of 75 to 80% of the Vo2max. In rat surgery, SOL and EDL muscles were extracted, followed by changes in SLN proteins, and intramuscular FNDC5 and PGC1α were measured by Western blotting technic. Data were statistically analyzed by independent t-test (P≤0.05). Results: The results of statistical analysis showed that four weeks of incremental endurance training caused significant changes in the amounts of SLN (P= 0.035), FNDC5 (P= 0.02), and PGC1α (P = 0.012) proteins. In the soleus muscle, compared to the control group. Also, in EDL muscle, significant changes were observed in the amounts of SLN (P= 0.01) and FNDC5 (P = 0.043) proteins in comparison with the control group, but in the changes of PGC1α protein in EDL muscle compared to the control group, no significant difference was observed (P= 0.17). Conclusion: According to the parameters of the study, it seems that endurance exercise can increase the amount of proteins related to thermogenesis and metabolism. | ||
| Keywords | ||
| Basal Metabolism; Incremental Endurance Training; Sarcolipin; Thermogenesis; Mitochondria | ||
| References | ||
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