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Transposable Elements as Regulators of Gene Expression, Evolutionary Forces, and Disease Contributors | ||
| Journal of Genetic Resources | ||
| دوره 11، شماره 1، 2025، صفحه 50-59 اصل مقاله (380.04 K) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22080/jgr.2025.28114.1411 | ||
| نویسندگان | ||
| Francis Ushie Ebuara1؛ Chinyere Mary-Cynthia Ikele* 2؛ Darin R Rokyta1 | ||
| 1Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA | ||
| 2Integrated Germline Biology Group Laboratory, Osaka University, Osaka, Japan | ||
| تاریخ دریافت: 03 آذر 1403، تاریخ بازنگری: 14 اسفند 1403، تاریخ پذیرش: 05 دی 1403 | ||
| چکیده | ||
| Transposable elements (TEs), once considered "junk DNA," are now recognized as significant players in gene regulation, genome evolution, and disease development. These mobile genetic sequences act as enhancers, promoters, or silencers, influencing gene expression in various species. This review explores the multifaceted roles of TEs in gene regulation, focusing on organisms such as maize, Drosophila, and mice. The present study closely examined the evolutionary impact of TEs, highlighting how they contribute to genetic diversity and innovation through chimeric transcripts and exaptation. This research also discussed the involvement of TEs by exertion of genomic instability and oncogenic activation in diseases like cancer, neurological disorders, and autoimmune conditions. Finally, it discussed experimental approaches for analyzing TE-fusion transcripts, providing insights into their evolutionary and pathogenic potentials. This comprehensive overview underscores the dual nature of TEs as drivers of genetic innovation and contributors to disease. It further highlights the need to study TE mechanisms to fully understand the complex roles of TEs in biology and disease. | ||
| کلیدواژه‌ها | ||
| Gene Regulation؛ Gene Expression؛ Evolution؛ Disease؛ Bioinformatics | ||
| مراجع | ||
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