آمار
| تعداد نشریات | 29 |
| تعداد شماره‌ها | 430 |
| تعداد مقالات | 4,199 |
| تعداد مشاهده مقاله | 6,793,497 |
| تعداد دریافت فایل اصل مقاله | 5,040,357 |
Effect of Vitamin C, as an Antioxidant, on Immobilization-Induced Changes in Sexual Behavior and Sperm Count in Male Mice | ||
| Journal of Genetic Resources | ||
| مقاله 3، دوره 2، شماره 2، آذر 2016، صفحه 81-87 اصل مقاله (812.53 K) | ||
| نوع مقاله: Research Article | ||
| شناسه دیجیتال (DOI): 10.22080/jgr.2017.12651.1063 | ||
| نویسندگان | ||
| Toktam Hajjar* ؛ Hadi Erfanianzade؛ Fateme Sadat Alavi | ||
| Department of Biology, Faculty of Science, Hakim Sabzevari University, Iran | ||
| تاریخ دریافت: 12 مرداد 1395، تاریخ بازنگری: 27 آبان 1396، تاریخ پذیرش: 07 مهر 1395 | ||
| چکیده | ||
| Sexual behavior in males is vulnerable to stress and it has been suggested that alterations in sexual behavior during stress is concomitant with spermatogenesis dysfunction. In this study, we investigated the effects of immobilization on sexual behavior and whether or not these effects are accompanied by changes in spermatogenesis process. The effect of antioxidant treatment on the sexual behavior and sperm count is also evaluated. 21 male mice were divided into the following three groups: control, immobilization stress (3 hours daily), and immobilization stress (3 hours daily) plus administration of 500 mg/kg of body weight vitamin C. Sexual behavior and sperm count were assessed after 60 days of stress and vitamin C treatment. Mount latency increased significantly, and the number of mounts showed significantly decreased in males exposed to immobilization but not in vitamin C treated mice. Moreover, sperm count decreased significantly in the stressed group but mice administrated vitamin C did not show a significant reduction in the number of sperms as compared with control unstressed animals. These results indicate that stress has great effects on sexual behavior and sperm count. Interestingly, administration of vitamin C resulted in a reversal in stress-induced inhibition in sexual behavior parameters, and sperm counts. | ||
| کلیدواژه‌ها | ||
| Immobilization؛ Vitamin C؛ Sexual behavior؛ Sperm count | ||
| مراجع | ||
|
Abdul Rahman S, Anwar NM, Basha S, Kamarzaman S. 2014. Impact of thymoquinone supplementation on immobilisation stress-induced changes in reproductive characteristics of male mice. J Appl Nat Sci 6: 1-5.
Abnosi MH, Amirjani M, Mahdiye M, Moradipoor H. 2015. Biochemical and cellular response of Catharanthus roseus callus cells to cadmium toxicity. J Genet Resour 1 (2): 101- 114.
Almeida SA, Petenusci SO, Franci JA, Rosa e Silva AA, Carbalho TL. 2000a. Chronic immobilization-induced stress increases plasma testosterone and delays testicular maturation in pubertal rats. Andrologia 32: 7-11.
Almeida SA, Kempinas WG, Lamano Carvalho TL. 2000b. Sexual behavior and fertility of male rats submitted to prolonged immobilization- induced stress. Braz J Med Biol Res 33: 1105-1109.
Ameen EM. 2009. Effect of stress on semen quality in a population of infertile Human. Kufa Med J 12(1):167-174.
Al-Zahrani S, Mohany M, Kandeal S, Badr G. 2012. Thymoquinone and Vitamin E supplementation improve the reproductive characteristics of heat stressed male mice. J Med Plants Res 6(3): 493-499.
Anisman H. 1999. Understanding stress: Characteristics and Caveats. Alcohol Res Health 23: 241-249.
Bharihoke V, Gupta M, Gohil H. 2000. Bronchopulmonary changes after repeated exposure to cold and restraint stress. J Anat Soc India 49 (1): 49-51.
Cockett ATK, Elbadawi A, Zemjanis R, Adey WR. 1970. The effects of immobilization on in subhuman primates. Fertil Steril 21:610-614.
Cockett ATK, Zemjanis R, Elbadawi A, Adey WR. 1971. Male infertility: histochemical changes in the subhuman primate testis after prolonged immobilization. Fertil Steril 22: 565- 572.
Collu R, Gibb W, Ducharme GR. 1984. Role of catecholamines in the inhibitory effect of immobilization stress on testosterone secretion in rats. Biol Reprod 30: 416-422.
Eriksen HR, Ursin H. 2002. Sensitization and subjective health complaints. Scand J Psychol 43 (2):189-96.
Ghosh D, Das UB, Mallick M, Debnath I. 2002. Testicular gametogenic and steroidogenic activities in cyclophosphamide treated rat: a correlative study with testicular oxidative stress. Drug Chem Toxicol 25: 28-292.
Goldfoot D, Baum M. 1972. Initiation of mating behavior in developing male rats following peripheral electric shock. Physiol Behav 8: 857– 863.
Gonzalaz MJ, Miranda-Massori JR, Mora EM, Guzman A, Riordan HD, Casciari JJ, Jackson JA, Román-Franco A. 2005. Orthomolecular oncology review: ascorbic acid and cancer 25 years later. Arch Biochem Biophys 4(1):32-44.
Hsu HG, Lee YT, Chen MF. 2002. Effect of fish oil and vitamin E on the antioxidant defense system in diet-induced hypercholesterolemic rabbits. Prostaglandins Other Lipids Mediat 66: 99-108.
Hu Y, Cardounel A, Gursoy E, Anderson P, Kalimi M. 2000. Anti-Stress effects of dehydroepiandrosterone: Protection of rats against repeated immobilization stress-induced weight loss, glucocorticoid receptor production, and lipid peroxidation. Biochem Pharmacol 59: 753-762.
Khandve B, Gujar V, Bokariya P, Tarnekar A, Shende M. 2013. Deranged spermatogenesis of adult swiss albino Mice as effect of immobilization stress-histological study. Iosr J Pharm 3 (2): 7- 10.
Manna I, Iana K, Samanta PK. 2003. Effect of exercise-induced testicular gametogenic and steroidogenic disorders in nature wistar strain rats: A Correlative Approach to Oxidative Stress. Acta Physiol Scan 178: 33-40.
Meisel RL, Sachs BD. 1994. The physiology of male sexual behavior. In: Knobil E, Neil J, eds. The physiology of reproduction. New York: Raven Press, 3-105.
Melis MR, Argiolas A. 1995. Dopamine and sexual behavior. Neurosci Biobehav Rev 19: 19-38.
Menendez-Patterson A, Flores-Lozano JA, Ferna´ndez S, Marin B. 1978. Stress and sexual behavior in male rats. Physiol Behav 24: 403–406.
Moazzam S, Hussain MM, Saleem S. 2012. Effect of ascorbic acid and alpha tocopherol on immune status of male sprague dawley rats exposed to chronic restraint stress. J Ayub Med Coll Abbottabad 24(3-4):31-35.
Monder C, Sakai RR, Miroff Y, Blanchard DC, Blanchard RJ. 1994. Reciprocal changes in plasma corticosterone and testosterone in stressed male rats maintained in a visible burrow system: Evidence for a mediating role of testicular 11-hydroxysteroid dehydrogenase. Endocrinology 134(4): 1193-1198.
Muthuvel R, Venkataraman P, Stanley A, Aruna Karan I. 2006. Antioxidant effect of ascorbic acid on PCB (Aroclor 1254) induced oxidative stress in hypothalamus of albino rat. Clin Chem Acta 365: 297-303.
Narayana K, D'Souza UJ, Rao KP. 2002. Effect of ribavirin on epididymal sperm count in rat. Indian J Physiol Pharmacol 46(1): 97-101.
Nirupama M, Yajurvedi HN. 2013. Durational effects of chronic stress on the testicular damage and its reversibility in albino rat. Eur J Exp Biol 3(5): 229-239.
Norman R, Smith C. 1992. Restraint inhibits luteinizing hormone and testosterone secretion in intact male Rhesus macaques: effects of concurrent naloxone administration. Neuroendocrinology 55: 405-415.
Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH, Chen S, Corpe C, Dutta A, Dutta SK, Levine M. 2003. Vitamin C as an antioxidant. Evaluation of its role in disease prevention. J Am Coll Nutr 22:18-35.
Pattij T, de Jong TR, Uitterdijk A, Waldinger MD, Veening JG, Cools AR, van der Graaf PH, Olivier B. 2005. Individual differences in male rat ejaculatory behavior: searching for models to study ejaculation disorders. Eur J Neurosci 22: 724-34.
Rather SA, Sarumathi A, Anbu S, Saravanan N. 2013. Gallic acid protects against immobilization stress-induced changes in wistar rats. J Stress Physiol Biochem 9 (1): 136-147.
Retana-Marquez S, Bonilla-Jaime H, Va´zquez-Palacios G, Martı´nez-Garcı´a R, Vela´zquez-Moctezuma J. 2003. Changes in masculine sexual behavior, corticosterone and testosterone in response to acute and chronic stress in male rats. Horm Behav 44: 327-337.
Taylor JM, Crack PJ. 2004. Impact of oxidative stress on neuronal survival. Clin Exp Pharmacol Physiol 31(7): 397-406.
Woo CC, Loo SY, Gee V, Yap CW, Sethi G, Kumar AP, Tan KH. 2011. Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway. Biochem Pharmacol 82(5): 464-475.
| ||
|
آمار تعداد مشاهده مقاله: 946 تعداد دریافت فایل اصل مقاله: 811 |
||