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Study of the Expression of miR-4270 in Plasma of Patients with Breast Invasive Ductal Carcinoma | ||
| Journal of Genetic Resources | ||
| مقاله 2، دوره 4، شماره 2، آذر 2018، صفحه 85-89 اصل مقاله (1.41 M) | ||
| نوع مقاله: Research Article | ||
| شناسه دیجیتال (DOI): 10.22080/jgr.2018.14802.1111 | ||
| نویسندگان | ||
| Faezeh Aminisepehr؛ Esmaeil Babaei* ؛ Mohammad Ali Hosseinpour Feizi | ||
| Department of Biological Sciences, School of Natural Sciences, University of Tabriz | ||
| تاریخ دریافت: 20 اسفند 1396، تاریخ بازنگری: 30 مهر 1397، تاریخ پذیرش: 06 خرداد 1397 | ||
| چکیده | ||
| Detection of tumor-specific microRNAs (miRs) in the blood of cancer patients may provide a unique and valuable biomarker for diagnosis and prognosis. The aim of this study was to investigate whether plasma levels of microRNA-4270 could serve as a potential marker for breast invasive ductal carcinoma. A total of 40 breast cancer patients and 28 controls were recruited in this study. Total RNA was extracted from plasma samples andmiR-4270 expression was evaluated by real-time polymerase chain reaction (PCR). The correlation between miR-4270 expression and clinicopathological characteristics were also studied. Our data showed that plasma miR-4270 is significantly up-regulated in patients compared to control group (P-value=0.00). In addition, data analysis illustrated a correlation between low plasma levels of miR-4270 and larger tumor size, lymph node metastasis and higher stages of malignancy (P-value > 0.05). The area under the curve of the ROC revealed thatmiR-4270 expression was not able to distinguish between tumor plasmas and nontumoral specimens. Current work shows preliminary data on the expression profile of-4270 in plasma of breast cancer patients. However, further studies are required to fully elucidate the role of circulating mix-4270 in breast ductal carcinoma. | ||
| کلیدواژه‌ها | ||
| Circulating microRNA؛ miR-4270؛ Breast cancer؛ Real-Time PCR | ||
| مراجع | ||
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