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Association of the -160 C>A Polymorphism in the CDH1 Promoter with Gastric Cancer: A Case-control Study | ||
| Journal of Genetic Resources | ||
| مقاله 1، دوره 5، شماره 1، خرداد 2019، صفحه 1-8 اصل مقاله (307.85 K) | ||
| نوع مقاله: Research Article | ||
| شناسه دیجیتال (DOI): 10.22080/jgr.2019.15741.1123 | ||
| نویسندگان | ||
| Majid Tafrihi* 1؛ Sogand Kalantari1؛ Mohammad Shokrzadeh2 | ||
| 1Molecular & Cell Biology Research Lab 2, Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran | ||
| 2Department of Toxicology, Faculty of Pharmacy, Mazandaran Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran | ||
| تاریخ دریافت: 14 آذر 1397، تاریخ بازنگری: 26 بهمن 1396، تاریخ پذیرش: 18 دی 1397 | ||
| چکیده | ||
| E-cadherin is a tumor suppressor protein that plays a crucial role in cell-cell adherens junction and tissue architecture and it is hypothesized to participate in carcinogenesis. It has been shown that a polymorphism in the upstream of the transcription start site of the CDH1 gene affects E-cadherin transcriptional regulation and seems to be associated with a variety of cancers. For the first time, we investigated the association of the rs16260 in the 5'-untranslated region of the CDH1 gene with gastric cancer in Iranian population. Seventy- eight patients with gastric cancer and 72 healthy individuals were included and genotyped for this SNP using the PCR-RFLP method. Our results showed that the frequency of the AA genotype in gastric cancer patients (16 of 78, 20.5%) was higher than healthy individuals (9 of 72, 12.5%), the frequency of the A allele in the patients group was higher than controls (OR=1.231, 95% CI= 0.772-1.962, p-value= 0.383), but statistical analysis revealed the absence of association between AA genotype and gastric cancer risk (OR=1.719, 95% CI= 0.656-4.502, p-value= 0.268). In conclusion, our results suggest that this substitution and the AA genotype have not a major impact on the individual’s susceptibility to gastric cancer, and therefore this SNP may be an ethnicity-dependent risk factor. Further works with larger sample size and including other criteria such as H. pylori infection status are needed for more accuracy. | ||
| کلیدواژه‌ها | ||
| Gastric cancer؛ CDH1؛ E-cadherin protein؛ promoter؛ Single nucleotide polymorphism | ||
| مراجع | ||
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