تأثیر تمرین استقامتی کوتاه مدت روی مسیر سیگنالینگ PGC-1α/FNDC5/BDNF در رت‌های پارکینسونی 6-OHDA

##Subramaniam SR, Chesselet M-F. Mitochondrial dysfunction and oxidative stress in Parkinson's disease. Progress in neurobiology. 2013;106:17-32.##Sriraksa N, Wattanathorn J, Muchimapura S, Tiamkao S, Brown K, Chaisiwamongkol K. Cognitive-enhancing effect of quercetin in a rat model of Parkinson's disease induced by 6-hydroxydopamine. Evidence-Based Complementary and Alternative Medicine. 2011;2012.##Corona J, Duchen M. PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s. Neurochem Res. 2016:1-9.##Petzinger G, Holschneider D, Fisher B, McEwen S, Kintz N, Halliday M, et al. The effects of exercise on dopamine neurotransmission in Parkinson’s disease: targeting neuroplasticity to modulate basal ganglia circuitry. Brain plasticity. 2015;1(1):29-39.##Tuon T, Valvassori SS, Dal Pont GC, Paganini CS, Pozzi BG, Luciano TF, et al. Physical training prevents depressive symptoms and a decrease in brain-derived neurotrophic factor in Parkinson's disease. Brain Research Bulletin. 2014;108:106-12.##YoonM-C, Shin M-S, Kim T-S, Kim B-K, Ko I-G, Sung Y-H, et al. Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson's rats. Neuroscience Letters. 2007;423(1):12-7.##Muñoz A, Corrêa CL, Villar-Cheda B, Costa-Besada MA, Labandeira-Garcia JL. Aging-related increase in Rho kinase activity in the nigral region is counteracted by physical exercise. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. 2015;71(10):1254-7.##Tuon T, Valvassori SS, Lopes-Borges J, Luciano T, Trom CB, Silva LA, et al. Physical training exerts neuroprotective effects in the regulation of neurochemical factors in an animal model of Parkinson’s disease. Neuroscience. 2012;227:305-12.##Chen MJ, Russo-Neustadt AA. Exercise activates the phosphatidylinositol 3-kinase pathway. Molecular Brain Research. 2005;135(1):181-93.##Landers MR, Kinney JW, Allen DN, van Breukelen F. A comparison of voluntary and forced exercise in protecting against behavioral asymmetry in a juvenile hemiparkinsonian rat model. Behavioural Brain Research. 2013;248(0):121-8.##Cohen AD. Role of Exercise and GDNF in an Animal Model of Parkinson's Disease: Implications for Neuroprotection: University of Pittsburgh; 2006.##Faherty CJ, Raviie Shepherd K, Herasimtschuk A, Smeyne RJ. Environmental enrichment in adulthood eliminates neuronal death in experimental Parkinsonism. Molecular Brain Research. 2005;134(1):170-9.##Farshbaf MJ, Ghaedi K, Megraw TL, Curtiss J, Faradonbeh MS, Vaziri P, et al. Does PGC1α/FNDC5/BDNF elicit the beneficial effects of exercise on neurodegenerative disorders? Neuromolecular medicine. 2016;18(1):1-15.##Wrann Christiane D, White James P, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, et al. ExerciseInduces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway. Cell Metabolism. 2013(0).##Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-[agr]-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481(7382):463-8.##Huh JY, Mantzoros CS. Irisin physiology, oxidative stress, and thyroid dysfunction: What next? Metabolism. 2015;64(7):765-7.##Sleiman SF, Henry J, Al-Haddad R, El Hayek L, Haidar EA, Stringer T, et al. Exercise promotesthe expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate. Elife. 2016;5:e15092.##Psilander N. The effect of different exercise regimens on mitochondrial biogenesis and performance. 2014.##Berchtold N, Chinn G, Chou M, Kesslak J, Cotman C. Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus. Neuroscience. 2005;133(3):853-61.##Ke Z, Yip SP, Li L, Zheng X-X, Tong K-Y. The effects of voluntary, involuntary, and forced exercises on brain-derived neurotrophic factor and motor function recovery: a rat brain ischemia model. PLoS One. 2011;6(2):e16643.##Rafie F, Shahbazi M, Naghdi N, Sheibani V, Shikh M. The Effects of Voluntary Exercise on Learning and Memory Deficit in Parkinson's Disease Model of Rats. 2016.##Ang E-T, Dawe GS, Wong PTH, Moochhala S, Ng Y-K. Alterations in spatial learning and memory after forced exercise. Brain Research. 2006;1113(1):186-93.##Carvalho MM, Campos FL, Coimbra B, Pêgo JM, Rodrigues C, Lima R, et al. Behavioral characterization of the 6-hydroxidopamine model of Parkinson’s disease and pharmacological rescuing of non-motor deficits. Molecular neurodegeneration. 2013;8(1):14.##Mabandla M, Kellaway L, Gibson ASC, Russell VA. Voluntary running provides neuroprotection in rats after 6-hydroxydopamine injection into the medial forebrain bundle. Metabolic brain disease. 2004;19(1-2):43-50.##Aguiar Jr AS, Duzzioni M, Remor AP, Tristão FSM, Matheus FC, Raisman-Vozari R, et al. Moderate-Intensity Physical Exercise Protects Against Experimental 6-Hydroxydopamine-Induced Hemiparkinsonism Through Nrf2-Antioxidant Response Element Pathway. Neurochem Res. 2016;41:1-9.##Choe M, Koo B-S, An GJ, Jeon S. Effects of treadmill exercise on the recovery of dopaminergic neuron loss and muscle atrophy in the 6-ohda lesioned parkinson's disease rat model. The Korean Journal of Physiology & Pharmacology. 2012;16(5):305-12.##Cho H-S, Shin M-S, Song W, Jun T-W, Lim B-V, Kim Y-P, et al. Treadmill exercise alleviates short-term memory impairment in 6-hydroxydopamine-induced Parkinson’s rats. Journal of exercise rehabilitation. 2013;9(3):354.##Tajiri N, Yasuhara T, Shingo T, Kondo A, Yuan W, Kadota T, et al. Exercise exerts neuroprotective effects on Parkinson's disease model of rats. Brain Research. 2010;1310(Supplement C):200-7.##Petzinger GM, Walsh JP, Akopian G, Hogg E, Abernathy A, Arevalo P, et al. Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. The Journal of neuroscience. 2007;27(20):5291-300.##Fisher BE, Petzinger GM, Nixon K, Hogg E, Bremmer S, Meshul CK, et al. Exercise‐induced behavioral recovery and neuroplasticity in the 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine‐lesioned mouse basal ganglia. Journal of neuroscience research. 2004;77(3):378-90.##Goes A, Souza L, Del Fabbro L, De Gomes M, Boeira S, Jesse C. Neuroprotective effects of swimming training in a mouse model of Parkinson’s disease induced by 6-hydroxydopamine. Neuroscience. 2014;256:61-71.##Murray DK, Sacheli MA, Eng JJ, Stoessl AJ. The effects of exercise on cognition in Parkinson’s disease: a systematic review. Translational neurodegeneration. 2014;3(1):5.##Cassilhas R, Lee K, Venâncio D, Oliveira M, Tufik S, Mello M. Resistance exercise improves hippocampus-dependent memory. Brazilian Journal of Medical and Biological Research. 2012;45(12):1215-20.##RojasVega S, Strأ¼der HK, Vera Wahrmann B, Schmidt A, Bloch W, Hollmann W. Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans. Brain Research. 2006;1121(1):59-65.##Oliveira NR, MarquesSO, Luciano TF, Pauli JR, Moura LP, Caperuto E, et al. Treadmill Training Increases SIRT-1 and PGC-1α Protein Levels and AMPK Phosphorylation in Quadriceps of Middle-Aged Rats in an Intensity-Dependent Manner. Mediators of inflammation. 2014;2014.##Patki G, Lau Y-S. Impact of exercise on mitochondrial transcription factor expression and damage in the striatum of a chronic mouse model of Parkinson's disease. Neuroscience letters. 2011;505(3):268-72.##Xia D-Y, Huang X, Bi C-F, Mao L-L, Peng L-J, QianH-R. PGC-1α or FNDC5 Is Involved in Modulating the Effects of Aβ1− 42 Oligomers on Suppressing the Expression of BDNF, a Beneficial Factor for Inhibiting Neuronal Apoptosis, Aβ Deposition and Cognitive Decline of APP/PS1 Tg Mice. Frontiers in aging neuroscience. 2017;9.##