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تأثیر تمرین هوازی با دو شدت متفاوت بر برخی از عوامل آنژیوژنزی در بافت کلیه موشهای صحرایی دیابتی | ||
پژوهشنامه فیزیولوژی ورزشی کاربردی | ||
مقاله 5، دوره 15، شماره 29، تیر 1398، صفحه 57-72 اصل مقاله (325.18 K) | ||
نوع مقاله: مقاله پژوهشی | ||
شناسه دیجیتال (DOI): 10.22080/jaep.2019.14244.1757 | ||
نویسندگان | ||
رزیتا فتحی* 1؛ فرزاد فعلی2؛ پژمان معتمدی3؛ حمید رجبی4؛ علی اکبر محمودی5 | ||
1دانشیار دانشکده علوم ورزشی، دانشگاه مازندران، بابلسر، مازندران، ایران. | ||
2دانشجوی دکتری فیزیولوژی ورزشی، دانشکده علوم ورزشی دانشگاه خوارزمی، کرج، ایران | ||
3استادیار دانشکده علوم ورزشی دانشگاه خوارزمی، کرج، ایران | ||
4استاد دانشکده علوم ورزشی دانشگاه خوارزمی،کرج، ایران | ||
5استادیار گروه پزشکی ورزشی دانشکده پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران | ||
تاریخ دریافت: 12 خرداد 1397، تاریخ بازنگری: 11 شهریور 1397، تاریخ پذیرش: 31 شهریور 1397 | ||
چکیده | ||
زمینه و هدف: در مبتلایان به دیابت به ویژه آنانی که به فعالیت ورزشی میپردازند، عوامل بازدارنده آنژیوژنز کنترل شده و عوامل پیش برنده آنژیوژنز تقویت میشود. هدف از پژوهش حاضر مقایسه اثرات تمرینات استقامتی با شدت متوسط و بالا بر برخی فاکتورهای محرک آنژیوژنز در بافت کلیه رتهای نر دیابتی میباشد. مواد و روشها: 60 سر موش صحرایی نر به 6 گروه (10 سر در هر گروه): کم تحرک کنترل (SC)، دیابتی کم تحرک (SD)، دیابتی تمرین با شدت متوسط (DMT)، تمرین با شدت متوسط سالم (MT)، دیابتی تمرین با شدت بالا (DHT) و تمرین با شدت بالا سالم ((HT تقسیم شدند. پروتکل تمرینی شامل 8 هفته تمرین هوازی با شدت متوسط و بالا، 5 جلسه در هفته و 60 دقیقه در هر جلسه بود. 48 ساعت پس از آخرین جلسه تمرین، موش ها بیهوش شدند و خونگیری و برداشت بافت کلیه برای سنجش گلوکز، VEGF وVEGFR1 انجام شد. یافته ها: هشت هفته تمرین هوازی با شدت متوسط و بالا باعث کاهش معنیدار گلوکز خون موشهای دیابتی شد، اما این کاهش در گروه DMT بیشتر بود. همچنین هشت هفته تمرین هوازی با شدت متوسط و بالا در هر دو گروه دیابتی باعث افزایش معنیدار VEGF (به ترتیب 002/0 = P و 0001/0 =P) نسبت به SD شد ولی در خصوص VEGFR1 فقط بین DHT نسبت به گروه SD تفاوت مشاهده شد (007/0 =P). نتیجه گیری: در مقایسه با تمرینات هوازی با شدت بالا، تمرینات هوازی با شدت متوسط موجب کاهش بیشتر سطوح گلوکز و افزایش VEGF می شوند. | ||
کلیدواژهها | ||
آنژیوژنز؛ VEGF؛ VEGFR1؛ تمرین هوازی؛ شدت تمرین؛ دیابت | ||
عنوان مقاله [English] | ||
Effect of Aerobic Training with Two Different Intensities on Some Angiogenesis Factors in Renal Tissue of Diabetic Rats | ||
نویسندگان [English] | ||
Rozita Fathi1؛ Farzad Feli2؛ Pezhman Motamedi3؛ Hamid Rajabi4؛ Aliakbar Mahmoudi5 | ||
1Exercise Physiology Department, Sport Science Faculty, University of Mazandaran, Babolsar, Iran. | ||
2Exercise Physiology Department, Sport Science Faculty, University of Kharazmi, Iran. | ||
3Exercise Physiology Department, Sport Science Faculty, University of Kharazmi, Karaj, Iran. | ||
4Exercise Physiology Department, Sport Science Faculty, University of Kharazmi, Karaj, Iran. | ||
5Department of Sport Medicine, Mazandaran University of Medical Science, Sari, Iran | ||
چکیده [English] | ||
Background and purpose: The angiogenesis inhibitors and the pro angiogenesis factors are enhanced in diabetic patients; especially those are involved in exercise. The purpose of this study was to compare the effects of endurance training with moderate and high intensities on some angiogenesis factors in renal tissue of diabetic rats. Materials and Methods: Sixty male rats were divided into 6 groups (n=10 per group): Sedentary control (SC), Sedentary Diabetic (SD), Diabetic Moderate intensity training (DMT), Healthy Moderate intensity training (MT), Diabetic High intensity training (DHT) and Healthy High intensity training (HT). The exercise protocol performed 8 weeks of moderate and high intensity aerobic training, 5 sessions per week and 60 minutes per session. Results: Eight weeks of moderate and high intensity aerobic training significantly reduced blood glucose in diabetic rats, but this decrease was higher in the DMT group. Also, eight weeks of moderate and high intensity aerobic training in both diabetic groups significantly increased VEGF (P = 0.002 and P = 0.000, respectively) compared to the SD, but for VEGFR1 was observed only between DHT compared to SD (P = 0.007). Conclusion: compared to high intensity aerobic training, moderate aerobic training results in a decrease in the levels of glucose and an increase in VEGF. | ||
کلیدواژهها [English] | ||
Angiogenesis, VEGF, VEGFR1, Aerobic Training, Training Intensity, Diabetes | ||
مراجع | ||
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