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اثر هشت هفته تمرین ترکیبی (هوازی- مقاومتی) همراه با مصرف مکمل کوآنزیم Q10 بر فعالیت آنزیمهای آنتیاکسیدانی و شاخص پراکسیداسیون لیپیدی در زنان مبتلا به مولتیپل اسکلروزیس با چرخه جنسی منظم | ||
پژوهشنامه فیزیولوژی ورزشی کاربردی | ||
مقاله 9، دوره 15، شماره 30، دی 1398، صفحه 145-160 اصل مقاله (548.46 K) | ||
نوع مقاله: مقاله پژوهشی | ||
شناسه دیجیتال (DOI): 10.22080/jaep.2019.15573.1841 | ||
نویسندگان | ||
صبا ابراهیمی* 1؛ امیر حسین حقیقی2؛ کریم نیکخواه3 | ||
1استادیارگروه تربیت بدنی، دانشگاه پیام نور، تهران، ایران | ||
2دانشیار گروه فیزیولوژی ورزش، دانشکده علوم ورزشی، دانشگاه حکیم سبزواری، سبزوار | ||
3دانشیار گروه مغز و اعصاب، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران | ||
تاریخ دریافت: 15 بهمن 1397، تاریخ بازنگری: 02 فروردین 1398، تاریخ پذیرش: 28 اردیبهشت 1398 | ||
چکیده | ||
زمینه و هدف: بخوبی مشخص شده که استرساکسیداتیو در مولتیپلاسکلروزیس(MS) سبب آسیب غشا لیپیدی و تخریب بافت عصبی میشود. هدف تحقیق حاضر، بررسی اثر هشت هفته تمرین ترکیبی (هوازی- مقاومتی) همراه با مصرف مکمل کوآنزیم Q10 بر عملکرد آنزیمهای آنتیاکسیدانی و شاخص پراکسیداسیون لیپیدی در زنان مبتلا به MS بود. مواد و روشها: 60 زن داوطلب مبتلا به MS انتخاب (میانگین سنی 9/15± 19/35 سال، وزن 6/13±2/59 کیلوگرم و مقیاس ناتوانی 6/0 ±5/3) و بهطور تصادفی در 4 گروه مساوی دارونما، مکمل، تمرین-دارونما و مکمل-تمرین قرار گرفتند. گروههای تجربی کوآنزیمQ10 و گروه کنترل(دارونما)، دارونما را به مقدار 300 میلیگرم در روز مصرف کردند. برنامه تمرین ترکیبی (هوازی-مقاومتی) به مدت 8 هفته، سه جلسه در هفته انجام شد. قبل و بعد از دوره تمرینی، برای بررسی تغییرات آنزیمهای سوپراکساید دیسموتاز(SOD)، گلوتاتیونپراکسیداز (GPX)، ظرفیت تام آنتیاکسیدانی (TAC)و میزان مالوندیآلدئید (MDA) از همه آزمودنیها در حالت ناشتا خونگیری به عمل آمد. برای مقایسه متغییرها از آزمون آنالیز واریانس اندازههای تکراری استفاده شد. ( P نتایج: سطوح سرمی سوپراکساید دیسموتاز و Q10 در هر سه گروه در مقایسه با گروه دارونما افزایش معناداری داشت (P=0.001). اما دیگر شاخصهای تحقیق (GPX,TAC,MDA) بین چهار گروه تفاوت معنا داری مشاهده نشد. نتیجه گیری: اگر چه انجام تمرینات ترکیبی با شدت متوسط همراه با مصرف مکمل کوآنزیم Q10 میتواند باعث افزایش غلظت سرمیSOD وQ10 این بیماران شود. اما تحقیق حاضر نتوانست تاثیر معنیداری بر بهبود ظرفیت آنتی اکسیدانی و شاخص پراکسیداسیون لیپیدیMDA) ) در زنان مبتلا به MS نشان دهد. لذا پیشنهاد میشود با توجه به نقش مخرب احتمالی استفاده همزمان مکمل آنتیاکسیدانی و فعالیت ورزشی، برای حفظ اثرات مثبت سازگار کننده فعالیت بدنی با شدت متوسط در بیماران MS مصرف مکملهای آنتی اکسیدانی محدود شود. | ||
کلیدواژهها | ||
سوپراکساید دیسموتاز؛ پراکسیداسیون لیپیدی؛ کوآنزیم Q10؛ تمرین ترکیبی؛ مولتیپل اسکلروزیس | ||
عنوان مقاله [English] | ||
The Effect of Combined Exercise (Aerobic-Resistance) with Consumption of Coenzyme Q10 on Antioxidant Enzyme Activities and Lipid Peroxidation in Female with Multiple Sclerosis sexual cycle | ||
نویسندگان [English] | ||
Saba Ebrahimi1؛ Amir hosein Haghighi2؛ Karim Nikkhah3 | ||
1Sport Science Branch, Payame Noor University, Tehran, Iran | ||
2Exercise Physiology Department, Sport Sciences Facuity, Hakim Sabzevari University, Sabzevar, Iran | ||
3Department of Neurology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
چکیده [English] | ||
Background&Purpose: It is well documented that oxidative stress provides neurodegenerative in multiple sclerosis (MS). The purpose of this study was to evaluate the effect of eight week combined exercise (aerobic- resistance) with consumption of coenzyme Q10 on antioxidant enzyme activities and lipid peroxidation in female with multiple sclerosis. Methodology: 60 women with multiple sclerosis (EDSS less than 4, 20-60 years old) were selected and randomly divided in to four equal, (Q10 (n=15), combined training-placebo (n=15), combined training-Q10 (n=15), placebo (n=15)) groups. For 8 weeks, experimental group and Control group consumed Q10 and placebo 300 mg CoQ10 daily, respectively. Subjects in experimental groups performed an aerobic-resistance training program for 8 weeks (3 sessions per week).Fastig blood sample was taken from all subjects before and after performing protocol. For within and between group mean difference comparison, Repeated measures Anova and Tocky were used, respectively (P< 0.05). Result: A repeated measures ANOVA showed that serum level of SOD and Q10 notable increase in experience groups than placebo group (p=0.001).But there was no significant difference in serum level of (MDA, GPX, TAC) between all groups (p>0.05). Conclusion: Although combined training with moderate intensity and coenzyme Q10 could increase serum level of SOD and Q10 in patients with Multiple Sclerosis .but failed to show any significant effects on the antioxidant capacity dnd MDA in woman with Moltiple Sclerosis. We suggest limited consumption of antioxidants supplementation during exercise, to save the adaptive effects of moderate exercise in patients with Multiple Sclerosis. | ||
کلیدواژهها [English] | ||
Superoxide Dismutase, Lipid Peroxidation, COQ10, Combined Training, Multiple Sclerosis | ||
مراجع | ||
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