اثر هشت هفته تمرین ترکیبی (هوازی- مقاومتی) همراه با مصرف مکمل کوآنزیم Q10 بر فعالیت آنزیم‌های آنتی‌اکسیدانی و شاخص پراکسیداسیون لیپیدی در زنان مبتلا به مولتیپل اسکلروزیس با چرخه جنسی منظم

##Kordi MR, Anooshe, Khodadade, Maghsodi, sanglachi, Hemmatinafar. Comparing the effect of three methods of combined training on serum levels of ghrelin, pro and anti-inflammatory cytokines in multiple sclerosis (MS) patients. Journal of Zanjan University of Medical Sciences. 2014;22( 91),[Persian].##Kjølhede T, Dalgas U, Gade A B, Bjerre M, Stenager E, Petersen T, Vissing K. Acute and chronic cytokine responses to resistance exercise and training in people with multiple sclerosis. Scand J Med Sci Sports.2016.1;26(7):824-34.##Moher DC. Pelletier DA .Temporal Frame work For Understanding the effect of stressful life event on inflammation in patient with multiple sclerosis. Journal of Brain, Behavior and Immunity.2005.20.pp:27-36.##Dalgas U, Stenager E, Jakobsen J, Peterse n T, Hansen H. J, Knudsen C, Overgaard K, Ingemann-Hansen T.Resistance training improves muscle strength and functional capacity in multiple sclerosis. Neurology.2009; 73(18): 1478-84.##Ebrahimi Atri, A., Sokhangoi, M., Sarvari, F.The comparison of resistance and endurance exercise on fatigue severity and balance in woman with multipl sclerosis.jurnal of sport medicin.2013; 5(1): 89-102 ,[Persian].##Saman-Nezhad B, Rezaee T, Bostani A, Najafi F, Aghaei A. Epidemiological characteristics of patients with multiple sclerosis in Kermanshah, Iran in 2012. Journal of Mazandaran University of Medical Sciences. 2013 Sep 15; 23(104):97-101. ,[Persian].##Sanglaji B. The effects of hayateno rehabilitation center multidisciplinary protocol on Multiple sclerosis patient's quality of life. University of Welfare and Rehabilitation Sciences. 2004 ,[Persian].##Souza-Teixeira F D, Costilla S, Ayán C, García-López D, González-Gallego J, Paz J A D. Effects of resistance training in multiple sclerosis. Int J Sports Med.2009; 30: 245-250.##Dendrou C A, Fugger L, Friese M A. (2015). Immuno pathology of multiple sclerosis. Nature Reviews Immunology. 15: 545-558.##Soleimani M, Jameie S B, Barati M, Mehdizadeh M, Kerdari M. Effects of coenzyme Q10 on the ratio of TH1/TH2 in experimental autoimmune encephalomyelitis model of multiple sclerosis in C57BL/6. Iranian Biomedical Journal. 2014; 18(4): 203-211,[Persian].##Almasi S, Rezvanjoo B, Shirazi-beheshtiha S.H, Namvaran-Abbas-Abad A, khosravi M. Protective effect of coenzyme Q10 and vitamin C on cysteamine induced lipid peroxidation. J.Vet.Clin. Res. 2014; 5(1)21-29,[Persian].##Jahani Gh.R, Firoozrai M, Matin Homaee H, Tarverdizadeh B, Azarbayjani M.A, Movaseghi Gh.R, Sarasghani R,   HedayatzadehR. The effect of continuous and regular exercise on erythrocyte ant oxidative enzymes activity and stress oxidative in young soccer players. Journal of Iran University of Medical Sciences2010; 17(74) ,[Persian].##Hagigholamali M, Jafari M, Asgari A.R, Haji Hossaini R, Abasnegad M, Salehi M, Salimian M. Effect of paraoxon on antioxidant system and lipid peroxidation in liver of rat. Journal of Guilan University of Medical Sciences.2009; N0:75: 1-10,[Persian].##Hejaze E, Amaani R, Sharafodin zadeh N.Dietaty intakeof antioxidant status (TAS) in MS patients with that of normal subject.  Yafte.2007;9(3):57-64,[Persian].##Tasset I, Aguera E, S´anchez-L´opez F, et al. Peripheral oxidative stress in relapsing–remitting multiple sclerosis. Clin Biochem.2012; 45(6):440–444.##LaFlamme, B., 2014. NF-[kappa][beta] signaling disrupted in neurodevelopmental disorders. Nature Genet. 46(9), 933-933.##Hininger-Favier, I., Osman, M., Roussel, A.M., et al., 2016. Positive effects of an oral supplementation by Glisodin, a gliadin-combined SOD-rich melon extract, in an animal model of dietary-induced oxidative stress. Phytothérapie, 14(1), 29-34.##Miller M, Mrowicka M, Malinowska K, Mrowicki J. The effects of whole-body cryo therapy on oxidative stress in multiple sclerosis patients. J.Med.Invest.2010;57:168-73.##White L J, Castellano V. Exercise and Brain Health –Implications for Multiple Sclerosis. Sports Med. 38(2): 91-100.##Afzalpour M, Gharakhanlou R, Gaeini A, Mohebbi H, Hedayati M, Khazaei M. The effects of aerobic exercises on the serum oxidized LDL and total antioxidant capacity in non-active men. CVD prevention and control. 2008; 3(2):77-82.##Sanoobar M, Eghtesadi SH, Azimi A, Khalili M, Khodadadi B, Jazayeri SH, Gohari M R, Aryaeian N. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing–remitting multiple sclerosis. Nutritional Neuroscience .2013;123(11): 776–782.##Taylor NF, Dodd KJ, Prasad D, Denisenco S. (2006). Progressive resistance exercise for people with multiple sclerosos. J Disabil Rehabil. 28(18):10-26.##Modir M, Daryanoosh F, Tanideh N, Mohamadi M, Firouzmand H. The effects of short and middle time’s aerobic exercise with high intensities on ingredients antioxidant in female Sprague dawley rats. Medical Journal of Mashhad University of Medical Sciences .2014; 57(3) P: 587-595,[Persian].##O'Malley PA. 2016. The past, present, and future of coenzyme Q10 supplementation update for the clinical nurse specialist. Clin Nurse Spec. 30(1):15-26.##Castro-Marrero J, Cordero MD, Segundo MJ, Saez-Francas N, Calvo N, Roman-Malo L, et al. 2015. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome? Redox Signal. 22(8):679-85.##Abadi A, Crane JD, Ogborn D, Hettinga B, Akhtar M, Stokl A, et al. 2013.Supplementation with alpha-lipoic acid, CoQ10, and vitamin E augments running performance and mitochondrial function in female mice. Plos One. 8(4):60-72.##Deichmann RE, Lavie CJ, Asher T, DiNicolantonio JJ, O'Keefe JH, Thompson PD.2015. The interaction between statins and exercise: mechanisms and strategies to counter the musculoskeletal side effects of this combination therapy. The Ochsner J. 15(4):429-37.##Rostami A, Jafari A, Mahmoodi R, Mahmoodi A. 2015. Effect of coenzyme Q10 supplementation on exercise response in some hematological parameters in nonathletes men. J Tabriz Uni Med Sci. 36(6): 28-33.##Gironi M, Borgiani B, Mariani E, Cursano C. Oxidative Stress is differentially present in multiple sclerosis courses, early evident, and unrelated to treatment. Journal of Immunology Research.2014; 26; 2014.##Hathcock J.N, Andrew Shao A. Risk assessment for coenzyme Q10 (Ubiquinone).Regulatory Toxicology and Pharmacology. 2006;45.282–288.##Ristow M, Zarse K, Oberbach A, Klöting N, Birringer M, Kiehntopf M, et al. Antioxidants prevent health-promoting effects of physical exercise in humans. Proceedings of the National Academy of Sciences. 2009; 106(21):8665-70.##Nakhostin-Roohi B. Exercise- induced Oxidative Stress- Is Antioxidants Supplementation Useful? Journal of Applied Exercise Physiology Mazadaran University. 2016;12(24):129-140.##Parandak K, Arazi H, Khoshkhahesh F, Nakhostin-Roohi B. The effect of two-week Lcarnitine supplementation on exercise-induced oxidative stress and muscle damage. Asian journal of sports medicine. 2014; 5(2):123.##Javanamani R, Nakhostin-Roohi B. The Effect of One-week Glutamine Supplementation on Oxidative Stress Indices in Healthy Young Men. Journal of Ardabil University of Medical Sciences. 2015; 15(1):83-9.##Bohlooli S, Barmaki S, Khoshkhahesh F, Nakhostin-Roohi B. The effect of spinach supplementation on exercise-induced oxidative stress. The Journal of sports medicine and physical fitness. 2015; 55(6):609-14.##Zimmermann MB. Vitamin and mineral supplementation and exercise performance. Schweiz Z Med Traumatol. 2003; 51(1):53–7.##Teixeira VH, Valente HF, Casal SI, Marques AF, Moreira PA. Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery. Med Sci Sports Exerc.2009; 41(9):1752-60.##Omran Waheed M, Al- Tukmagi H, Kadhim Kareem A. Evaluate the effect of coenzyme q10 supplementation on reducing oxidative stress in patients with relapsing remitting Multiple Sclerosis. International Journal of Science and Research (IJSR).2014;4(11):2262-2264.##Balercia, G, Mosca, F, Mantero, F, Boscaro, M, Mancini, A, Ricciardo, Lamonica, G, Littarru, G. Coenzyme Q (10) supplementation in infertile men with idiopathic asthenozoospermia. An open, uncontrolled Pilot study. Fertile. Sterile.2004; 81: 93–98.##Watts, G.F, Playford, D.A, Croft, K.D, Ward, N.C, Mori, T.A, Burke,V. Coenzyme Q (10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus. Diabetologia.2002; 45: 420–426.##Haghighi A, Heshmati Kia A, Hosseini A. (2013).The Effect of Caffeine And Ephedrine Supplement And Their Combination on Maximal Strength And Muscular Endurance in Male bodybuilders. Journal of sport Bioscienes;5(4)P:89-107.##Shin YA, Lee JH, Song W, Jun TW. (2008). Exercise training improves the antioxidant enzyme activity with no changes of telomere length. J Appl Physiol; 129: 254-60.##Mc Bride JM, Kraemer WJ. Free radicals, exercise and antioxidants. Med Sci Sports Exerc; 1999.13(2): 175-83.##Gomez-Cabrera M-C, Domenech E, Viña J. Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radical Biology and Medicine. 2008; 44(2):126-31.##Wilson D, Johnson P. Exercise modulates antioxidant enzyme gene expression in rat myocardium and liver. Journal of Applied Physiology. 2000; 88(5):1791-6.##Radák Z, Apor P, Pucsok J, Berkes I, Ogonovszky H, Pavlik G, et al. Marathon running alters the DNA base excision repair in human skeletal muscle. Life sciences. 2003; 72(14):1627-33.##Powers SK, Ji LL, Leeuwenburgh C. (1999). Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. Medicine and science in sports and exercise. 31(7):987-97.##Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, Rasmussen C, Greenwood M, Leutholtz B, Willoughby D, &Kreider R. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. Journal of the International Society of Sports Nutrition. 2008; 5(8).##Gϋl I, Gökbel H, Belvİranli M, Okudan N, Bϋyϋkbas S, Basarali K. (2011). Oxidative stress and antioxidant defense in plasma after repeated bouts of supramaximal exercise: the effect of coenzyme Q10. J Sport Med Phys Fitness; 51: 305-312.##Mattson MP. (1998). Modification of ion homeostasis by lipid peroxidation: roles in neural degeneration and adaptive plasticity. TINS; 21: 1-9.##Kaikkonen J, Kosonen L, Nyyssonen K, Porkkala-Sarataho E, Salonen R, Korpela H, et al. Eeefect of combined coenzyme Q10 and d-alpha-tocopherol acetate supplementation on exercise induced lipid peroxidation and muscular damage: A placebo- controlled double-blind study in marathon runners. FreeRadic Res. 1998; 29: 85-92.##Saha SP, Whayne TF. 2016. Coenzyme Q10 in Human Health: Supporting Evidence? South Med J. 109(1):17-21.##