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MiR-490-5p Functions as an OncomiR in Breast Cancer by Targeting NFATc4 | ||
| Journal of Genetic Resources | ||
| مقاله 10، دوره 6، شماره 1، 2020، صفحه 77-84 اصل مقاله (1 M) | ||
| نوع مقاله: Research Article | ||
| شناسه دیجیتال (DOI): 10.22080/jgr.2020.18492.1177 | ||
| نویسندگان | ||
| Amir Hassan Nikfarjam* ؛ Mohsen Gholami | ||
| Department of Laboratory Sciences, Kashan Branch, Islamic Azad University, Kashan, Iran | ||
| تاریخ دریافت: 14 فروردین 1399، تاریخ بازنگری: 19 اردیبهشت 1399، تاریخ پذیرش: 08 بهمن 1398 | ||
| چکیده | ||
| Breast cancer is a serious health problem worldwide in women. MicroRNAs are small non-coding RNAs of 18–25 nucleotides in length that post-transcriptionally modulate gene expression. MiR-490 has been reported as a tumor suppressor and oncomiR microRNA in breast cancer with two separate targets, NFAT and Rho. NFAT is one of the targets for miR-490 but the relationship between hsa-miR-490 and NFATc3, NFATc4 are not clear yet. Except for NFAT5, the other members of NFAT are activated by Ca2+ influx in the cell, either via the PLC-γ pathway or via store-operated Ca2+ entry, typically in T lymphoid cells. In a cross-sectional comparative study, peripheral blood samples were collected from 30 subjects with breast cancer and 30 healthy individuals as a control group. Gene expression analysis of peripheral blood mononuclear cells (PBMCs) was performed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) to study the NFATc3, NFATc4, and hsa-miR-490-5p gene expression alterations. As per the obtained results, a significant decrease was observed in the expression level of NFATc4 (p <0.05), while hsa-miR-490-5p expression found to be elevated in PBMCs of breast cancer patient (p <0.05). Expression changes were not significant for NFATc3 gene (P>0.05). Taken together findings of this study indicated that serum hsa-miR-490-5p acts as an oncomiR by direct targeting the NFATc4. | ||
| کلیدواژه‌ها | ||
| hsa-miR-490-5p؛ NFATc3؛ NFATc4؛ Breast cancer؛ PBMCs | ||
| مراجع | ||
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