تاثیر شش هفته تمرین تناوبی خیلی شدید بربیان P53 و SRF در بافت تومور موش های ماده مبتلا به سرطان پستان

##Waks A, Winer E, 2019, Breast Cancer Treatment, JAMA,321(3), 288. ##Torre LA, Siegel RL, Ward EM , Ahmedin J,  2016, Global Cancer Incidence and Mortality Rates and Trends--An Update, Cancer Epidemiol Biomarkers Prev, 25(1), 16-27##.Hanahan D, Weinberg RA, 2011, Hallmarks of cancer, the next generation, Cell, 144(5), 646-674. ##Teodoro J, Evans S, Green M, 2007, Inhibition of tumor angiogenesis by p53, a new role for the guardian of the genome, Journal of Molecular Medicine. 85(11), 1175-1186. ##Folkman J, 1971.Tumor angiogenesis, therapeutic implications, N Engl J Med, 285(21), 1182-1186. ##Brown GC, Borutaite V, 2012. There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells, Mitochondrion, 12(1), 1-4. ##Chai J, 2011, Gastric ulcer healing - Role of serum response factor, In: Chai J, editor, Peptic Ulcer Disease, Rijeka, Croatia, InTech, p, 143-164. ##Suzuki H, Tomida A, Tsuruo T, 2001, Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia, Oncogene, 20(41), 5779-5788. ##Yang Y, Li C-CH, Weissman AM, 2004, Regulating the p53 system through ubiquitination, Oncogene, 23(11), 2096-2106. ##Kaluzova M, Kaluz S, Lerman M, Stanbridge E, 2004, DNA Damage Is a Prerequisite for p53-Mediated Proteasomal Degradation of HIF-1  in Hypoxic Cells and Downregulation of the Hypoxia Marker Carbonic Anhydrase IX, Molecular and Cellular Biology, 24(13), 5757-5766. ##Chai J, Jones MK, Tarnawski AS, 2004, Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis, The FASEB Journal, 18(11),1264-1266. ## Makrilia N,  Lappa T,  Xyla V,  Nikolaidis I,  Syrigos K, 2009, The role of angiogenesis in solid tumours, an overview, Eur J Intern Med, 20(7), 663-671. ##Hojman P, Gehl J, Christensen JF, Pedersen BK, 2017, Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment, Cell Metab ##Koelwyn GJ, Quail DF, Zhang X, White RM, Jones LW, 2017, Exercise-dependent regulation of the tumour microenvironment, Nat Rev Cance, 17(10), 620-632. ## Marcinko K,  Sikkema SR,  Samaan MC,  Kemp BE ,  Fullerton MD,  Steinberg GR,  2015, High intensity interval training improves liver and adipose tissue insulin sensitivity, Molecular metabolism, 4(12), 903-915. ## Amani Shalamzari S, Agha-Alinejad H,  Alizadeh S,  Shahbazi S,  Kashani Khatib Z,  Kazemi A,  Saei MA,   Minayi N, 2014, The effect of exercise training on the level of tissue IL-6 and vascular endothelial growth factor in breast cancer bearing mice, IJBMS, 17(4), 231-236]Persion[.## Leung PS, Aronson WJ, Ngo TH, Golding LA, Barnard RJ, 2004, Exercise alters the IGF axis in vivo and increases p53 protein in prostate tumor cells in vitro, J Appl Physiol, 96(2), 450-454. ##Miao Yu , King  B, Ewert E , Xiaoyu Su , Mardiyati N, Zhao Z,  Wang W, 2016, Exercise Activates p53 and Negatively Regulates IGF-1 Pathway in Epidermis within a Skin Cancer Model. PLoS One, 11(8), e0160939. ##Higgins KA, Park D, Lee GY, Curran WJ, Deng X, 2014, Exercise-induced lung cancer regression: mechanistic findings from a mouse model, Cancer, 120(21), 3302-3310. ## Asghari Rakabdarkolaee M, Barari A,  Abdi A, K Hasrak K, 2018,The Effec of Eight-Week Concurrent Training on Aerobic Capacity and Serum Level of P53 Tumor Suppressor Protein in Prostate Cancer Patients: A Clinical Trial, JRUMS, 17 (8), 731-744 ]Persion.[ ## Shirvani H, Isanejad A, Rahimi M,  Bazgir B ,  Alizadeh AM,  2018, Changes in monocarboxylate transporter 1 and P53   gene expression by aerobic interval training in the experimental colon carcinoma of mouse, JT UM, 76(5), 313-320] Persion.[ ##Moradpour p, Daryanoosh F, Dashtiyan A A, Taghi M, Jamhiri I, 2017, Impact of 6 weeks of intensiveintermittent training with taking vitamin E on P53 changes in blood serum levels and visceral adipose tissue in Sprague-Dawley rats, Sport Science, Vol,10 No,Suppl, 1 pp ,98-103[Persion.[ ##Afzalpour ME, Tanideh N, Sepehrimanesh M, Dashtiyan AA, 2016,The effect of intense intermittent training with and without taking vitamin E on mRNA expression of p53/PTEN tumor suppressing genes in prostate glads of male rats, I J M R & H S, 5 (11), 521-528. ## Dashtiyan AA ,  Afzalpour MA,  Tanideh N, Sepehrimanesh M, The comparison of The effect of vitamin E on the expression of P53/PTEN of prodtate gland of male rats in two groups of intensive continuous and intermittent exercise training. JFUMS, 2017; 7(3), 406-415,]Persion.[ ## Lin K,  Hsu PP,  Chen BP ,  Yuan S,  Usami S,  Shyy JY,  Li YS,  Chien S, 2000, Molecular mechanism of endothelial growth arrest by laminar shear stress, PNASUSA, 97(17), 9385-9389. ## Rudnicki M,  Faine L A, Dehne N,  Namgaladze D,  Ferderbar S,  Weinlich R,  Amarante-Mendes G P, Yan CYI,  Krieger JE,  Brüne B,  Abdalla D S P, 2011, Hypoxia inducible factor-dependent regulation of angiogenesis by nitro-fatty acids, Arteriosclerosis, thrombosis, vascular biology, 31(6), 1360-1367. ##Salvado MD, Alfranca A, Haeggström JZ, Redondo JM, 2012, Prostanoids in tumor angiogenesis: therapeutic intervention beyond COX-2, Trends Mol Med, 18(4), 233-243. ##Martinou JC, Youle R J, 2011, Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics, Developmental Cell, 21(1), 92-101. ##Koelwyn GJ, Quail DF, Zhang X, White RM, Jones LW, 2017, Exercise-dependent regulation of the tumour microenvironment, Nat Rev Cancer, 17(10), 620-632 . ##Wragg JW, Durant S, McGettrick HM, Sample KM, Egginton S, Bicknell R, 2014, Shear stress regulated gene expression and angiogenesis in vascular endothelium, Microcirculation, 21(4), 290-300. ##