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تاثیر تمرینات ورزشی ترکیبی با دو الگوی متفاوت بر سطوح پلاسمایی اینترلوکین 15، نیمرخ لیپیدی و شدت استئاتوز در زنان چاق یا دارای اضافهوزن مبتلا به کبد چرب | ||
پژوهشنامه فیزیولوژی ورزشی کاربردی | ||
مقاله 8، دوره 17، شماره 34، مهر 1400، صفحه 125-140 اصل مقاله (760.99 K) | ||
نوع مقاله: مقاله پژوهشی | ||
شناسه دیجیتال (DOI): 10.22080/jaep.2022.22115.2060 | ||
نویسندگان | ||
سمیه رجبی* 1؛ رویا عسکری2 | ||
1استادیار گروه فیزیولوژی ورزشی, دانشکده علوم انسانی، واحد شاهرود، دانشگاه آزاد اسلامی، شاهرود، ایران | ||
2دانشیار گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه حکیم سبزواری، سبزوار، ایران. | ||
تاریخ دریافت: 21 مرداد 1400، تاریخ بازنگری: 24 بهمن 1400، تاریخ پذیرش: 13 شهریور 1401 | ||
چکیده | ||
زمینه و هدف: اینترلوکین 15 (IL-15) سایتوکاینی است که به عنوان یک شاخص آنابولیک عضلانی شناخته میشود؛ با این وجود، التهاب ناشی از IL-15، بیماری کبد چرب غیرالکلی را تشدید میکند. امروزه استفاده از درمانهای کمکی غیر دارویی مورد توجه متخصصان سلامت میباشد. هدف از این پژوهش، بررسی تاثیر تمرینات ترکیبی با دو الگوی متفاوت بر سطوح پلاسمایی IL-15، شدت استئاتوز کبدی و نیمرخ لیپیدی در زنان چاق یا دارای اضافه وزن مبتلا به کبد چرب بود. مواد و روشها: تعداد 33 زن مبتلا به کبد چرب (سن 5/7 ± 43 سال و شاخص توده بدنی 6 ± 84/32 کیلوگرم بر متر مربع) به صورت تصادفی به دو گروه تمرینی و کنترل تقسیم شدند. گروه تمرین ترکیبی1، تمرین مقاومتی دایره ای همراه با تمرین اینتروال هوازی (5-2 ست 4 دقیقهای، شدت 75-70 درصد حداکثر ضربان قلب) و گروه ترکیبی 2، تمرین مقاومتی دایره ای به همراه تمرین اینتروال شدید (13-8 ست یک دقیقهای، 95-85 درصد حداکثر ضربان قلب) را به مدت 12 هفته، اجرا کردند. سنجش متغیرهای آنتروپومتریک، اولتراسونوگرافی و نمونهگیری خونی قبل و بعد از مداخله انجام شد. نتایج: هر دو نوع تمرین ترکیبی باعث کاهش معنادار درصد چربی بدن شد (001/0>P). تمرین ترکیبی 1 باعث کاهش معنادار (008/0=P) و تمرین ترکیبی 2 باعث کاهش غیرمعنادار شدت استئاتوز کبدی نسبت به گروه کنترل شد (07/0=P). بین دو گروه تمرین ترکیبی و گروه کنترل در میزان IL-15 تفاوت معناداری وجود نداشت. در سایر شاخصهای آنتروپومتریکی و نیمرخ لیپیدی تفاوت معناداری بین گروهها مشاهده نشد. نتیجهگیری: با توجه به نتایج، هر دو نوع تمرین ترکیبی، تغییر معناداری در مقادیر IL-15 پلاسما و نیمرخ لیپیدی ایجاد نکرد، اما سبب بهبود در شدت استئاتوز و درصد چربی بدن در افراد چاق یا دارای اضافهوزن مستقل از کاهش وزن شد. بنابراین به نظر میرسد ترکیبی از تمرینات مقاومتی و اینتروال هوازی در تحقیق حاضر، احتمالا بتواند به عنوان یک درمان غیردارویی کمکی در کاهش شدت استئاتوز کبدی و بهبود بیماران کبد چرب مورد استفاده قرار گیرد. | ||
کلیدواژهها | ||
تمرین ترکیبی؛ اینترلوکین 15؛ استئاتوز کبدی؛ نیمرخ لیپیدی؛ کبد چرب | ||
عنوان مقاله [English] | ||
The effect of combined training with two different patterns on IL-15, lipid profile and severity of steatosis in obese or overweight women with fatty liver | ||
نویسندگان [English] | ||
Somayeh Rajabi1؛ Roya Askari2 | ||
1Department of exercise physiology, Faculty of Human Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran | ||
2Department of exercise physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran | ||
چکیده [English] | ||
Background & Purpose: Interleukin 15 (IL-15) is a cytokine that is known as an anabolic factor for skeletal muscle. However, Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease. Today, the use of non-pharmacological adjuvant therapies is considered by health professionals. The purpose of this study was to investigate the effect of combined training with two different patterns on plasma IL-15 levels, severity of hepatic steatosis and lipid profile in obese or overweight women with fatty liver. Methodology: 33 women with fatty liver (age 43.45 ± 7.57 and Body Mass Index 32.84 ± 6) were randomly divided to training groups and control. Combined training group 1 performed circular resistance training with aerobic interval training (2-5 intervals of 4 minutes, intensity of 70-75% of maximum heart rate) and combined training 2 performed circular resistance training with high intensity interval training (8-13 intervals of 1 minutes, 85-95% maximum heart rate) for 12 weeks. Measurement of anthropometric variables, ultrasonography and blood sampling were performed before and after the intervention. Results: Both types of combined trainings significantly reduced body fat percentage (P<0.001). Combined training 1 caused a significant reduction (P=0.008) and combined training 2 caused a non-significant reduction in the severity of hepatic steatosis compared to the control group (P=0.07). There was no significant difference in IL-15 levels between the combined training groups and the control group (P<0.05). There was no significant difference between the groups in other anthropometric indices and lipid profile. Conclusion: According to the results, it seems that a combination of resistance and aerobic interval training in the present study, can probably be used as an adjuvant non-pharmacological treatment to reduce the severity of hepatic steatosis and improve fatty liver patients. | ||
کلیدواژهها [English] | ||
Combined Training, Interleukin 15, Hepatic Steatosis, Fatty Liver | ||
مراجع | ||
##Almendro, V., Busquets, S., Ametller, E., Carbó, N., Figueras, M., Fuster, G., . . . López-Soriano, F. J. (2006). Effects of interleukin-15 on lipid oxidation: disposal of an oral [14C]-triolein load. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1761(1), 37-42. ##Attia, D., Ali, H., El-Sayed, S., El Batanony, M., & Badr, N. (2017). Effect of high intensity interval training versus resistance training on quality of life and functional capacity on patients with fatty liver diseases (part I). Egyptian Journal of Occupational Medicine, 40(1), 61-70. ##Baghersad Renani, L., & Ravasi, A. A. (2019). The role of NADPH oxidase 2 in regulating IL-15 and PGC-1α gene expressions following a period of high intensity interval training. Iranian Journal of Endocrinology and Metabolism, 20(5), 263-272. ##Barani, F., Afzalpour, M. E., Ilbiegi, S., Kazemi, T., & Mohammadi Fard, M. (2014). The effect of resistance and combined exercise on serum levels of liver enzymes and fitness indicators in women with nonalcoholic fatty liver disease. Journal of Birjand University of Medical Sciences, 21(2), 188-202. ## Bazgir, B., Salesi, M., Koushki, M., & Amirghofran, Z. (2015). Effects of eccentric and concentric emphasized resistance exercise on IL-15 serum levels and its relation to inflammatory markers in athletes and non-athletes. Asian journal of sports medicine, 6(3), e27980. ## Burgomaster, K. A., Howarth, K. R., Phillips, S. M., Rakobowchuk, M., MacDonald, M. J., McGee, S. L., & Gibala, M. J. (2008). Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. The Journal of physiology, 586(1), 151-160. ## Cepero-Donates, Y., Lacraz, G., Ghobadi, F., Rakotoarivelo, V., Orkhis, S., Mayhue, M., . . . Ilangumaran, S. (2016). Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease. Cytokine, 82, 102-111. ##Cho, J., Kim, S., Lee, S., & Kang, H. (2015). Effect of training intensity on nonalcoholic fatty liver disease. Medicine and science in sports and exercise, 47(8), 1624. ##Chun, S. K., Lee, S., Yang, M.-J., Leeuwenburgh, C., & Kim, J.-S. (2017). Exercise-induced autophagy in fatty liver disease. Exercise and sport sciences reviews, 45(3), 181. ##Devries, M. C., Samjoo, I. A., Hamadeh, M. J., & Tarnopolsky, M. A. (2008). Effect of endurance exercise on hepatic lipid content, enzymes, and adiposity in men and women. Obesity, 16(10), 2281-2288. ##Donates, Y. C., Mayhue, M., Ilangumaran, S., & Ramanathan, S. (2017). IL-15 Dependent Lymphocyte Subsets Contribute to Fatty Liver Disease. Journal of Clinical and Experimental Hepatology, 7, S41. ##dos Santos, T., Lira, F. S., & Antunes, B. M. (2020). Interleukin-15 and creatine kinase response to high-intensity intermittent exercise training. Sport Sciences for Health, 16(3), 479-484. ##Duvnjak, M., Tomasic, V., Gomercic, M., Smircic Duvnjak, L., Barsic, N., & Lerotic, I. (2009). Therapy of nonalcoholic fatty liver disease: current status. J Physiol Pharmacol, 60(Suppl 7), 57-66. ##Gibala, M. J., & Jones, A. M. (2013). Physiological and performance adaptations to high-intensity interval training. Limits of human endurance, 76, 51-60. ##Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011). The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nature reviews immunology, 11(9), 607-615. ##Hallsworth, K., Thoma, C., Hollingsworth, K. G., Cassidy, S., Anstee, Q. M., Day, C. P., & Trenell, M. I. (2015). Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease: a randomized controlled trial. Clinical science, 129(12), 1097-1105. ## Hosseinian, M., Banitalebi, E., & Amirhosseini, S. (2016). Effect of 12 weeks of intensive interval and combined training on apolipoprotein A and B, Visfatin and Insulin resistance in overweight middle-aged women with type 2 diabetes. The Horizon of Medical Sciences, 22(3), 237-245. ##Jackson, A. S., & Pollock, M. L. (1978). Generalized equations for predicting body density of men. British journal of nutrition, 40(3), 497-504. ##Kaki, A., & Galedari, M. (2017). The effect of 12 weeks high intensity interval training and resistance training on liver fat , liver enzymes and insulin resistance in men with nonalcoholic fatty liver. Jundishapur Scientific Medical Journal, 16(5), 493-505. ##Kazemzadeh, Y., Banaeifar, A., Shirvani, H., & Gharaat, A. (2016). The effect of high intensity interval training HIIT on body composition, lipid profile and insulin sensitivity in overweight young men. Sports physiology and physical activity, 9(2), 1385-1394. ##Keating, S. E., George, J., & Johnson, N. A. (2015). The benefits of exercise for patients with non-alcoholic fatty liver disease. Expert review of gastroenterology & hepatology, 9(10), 1247-1250. ##Kistler, K. D., Brunt, E. M., Clark, J. M., Diehl, A. M., Sallis, J. F., Schwimmer, J. B., & Group, N. C. R. (2011). Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease. The American journal of gastroenterology, 106(3), 460. ##Kurinna, O., Fadieienko, G., Babak, O., Solomentseva, T., & Syntyk, K. (2015). Interleukin 15 in nonalcoholic fatty liver disease and obesity. Paper presented at the 50thThe International Liver Congress. ##López-Soriano, J., Carbó, N., Almendro, V., Figueras, M., Ribas, V., Busquets, S., . . . Argilés, J. M. (2004). Rat liver lipogenesis is modulated by interleukin-15. International journal of molecular medicine, 13(6), 817-819. ## Mardanpour-Shahrekordi, Z., Banitalebi, E., Faramarzi, M., Bagheri, L., & Mardanpour-Shahrekordi, E. (2015). The effect of sequence order of combined training (resistance and endurance) on strength, aerobic capacity and body composition in older women: a randomized clinical trial. Journal of Shahrekord University of Medical Sciences, 17(3), 1-12. ##Peake, J., Della Gatta, P., Suzuki, K., & Nieman, D. (2015). Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects. Exercise immunology review, 21, 8-25. ##Pedersen, B. K., & Febbraio, M. A. (2012). Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nature Reviews Endocrinology, 8(8), 457-465. ## Pérez-López, A., Gonzalo-Encabo, P., Pérez-Köhler, B., García-Honduvilla, N., & Valadés, D. (2021). Circulating myokines IL-6, IL-15 and FGF21 response to training is altered by exercise type but not by menopause in women with obesity. European Journal of Sport Science(just-accepted), 1-22. ##Prestes, J., Shiguemoto, G., Botero, J. P., Frollini, A., Dias, R., Leite, R., . . . Cavaglieri, C. (2009). Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post-menopausal women. Journal of sports sciences, 27(14), 1607-1615. ##Ramanathan, S., Lacraz, G., Donates, Y. C., Mayhue, M., Langois, M. F., Pleszczynski, M. R., & Ilangumaran, S. (2014). Interleukin-15 in the Regulation of Obesity and Fatty Liver Disease. Journal of Clinical and Experimental Hepatology, 4, S32. ##Rasheh, S., & Ahmadi, M. (2021). The Effects of High-intensity Interval Training and Probiotic Consumption on Interleukin-10 and Interferon-gamma Gene Expression of Gut Tissue in an Animal Model of Fatty Liver. The Horizon of Medical Sciences, 27(3), 342-357. ##Ratziu, V. (2017). Non‐pharmacological interventions in non‐alcoholic fatty liver disease patients. Liver International, 37(1), 90-96. ## Rinnov, A., Yfanti, C., Nielsen, S., Åkerström, T. C., Peijs, L., Zankari, A., . . . Pedersen, B. K. (2014). Endurance training enhances skeletal muscle interleukin-15 in human male subjects. Endocrine, 45(2), 271-278. ## Sarhadi M, N. F. M., Hassanzadeh K. (2017). Comparing Plasma Levels of C-Reactive Protein, Interleukin-10 and -15 in Physically Active and Sedentary Postmenopausal Women. Iranian Journal of Ageing, 12(1), 104-115. ##Schnyder, S., & Handschin, C. (2015). Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise. Bone, 80, 115-125. ##Shamsoddini, A., Sobhani, V., Chehreh, M. E. G., Alavian, S. M., & Zaree, A. (2015). Effect of aerobic and resistance exercise training on liver enzymes and hepatic fat in Iranian men with nonalcoholic fatty liver disease. Hepatitis monthly, 15(10), e31434. ##Shojaee-Moradie, F., Cuthbertson, D., Barrett, M., Jackson, N., Herring, R., Thomas, E., . . . Umpleby, A. (2016). Exercise training reduces liver fat and increases rates of VLDL clearance but not VLDL production in NAFLD. The Journal of Clinical Endocrinology & Metabolism, 101(11), 4219-4228. ## Siavoshy, H. (2015). Effects of two type exercise training programs on body composition of adolescence with Down syndrome. Exceptional Education, 3(131), 65-72. ##So, B., Kim, H.-J., Kim, J., & Song, W. (2014). Exercise-induced myokines in health and metabolic diseases. Integrative medicine research, 3(4), 172-179. ##Suzuki, A., McCall, S., Choi, S. S., Sicklick, J. K., Huang, J., Qi, Y., . . . Diehl, A. M. (2006). Interleukin-15 increases hepatic regenerative activity. Journal of hepatology, 45(3), 410-418. ##Thomas, S., Reading, J., & Shephard, R. J. (1992). Revision of the physical activity readiness questionnaire (PAR-Q). Canadian journal of sport sciences, 17(4), 338-345. ##Tresierras, M. A., & Balady, G. J. (2009). Resistance training in the treatment of diabetes and obesity: mechanisms and outcomes. Journal of Cardiopulmonary Rehabilitation and Prevention, 29(2), 67-75. ## | ||
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