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Correlation between Lipid Peroxidation and Lipoprotein (a) Levels in Patients with Coronary Artery Disease | ||
| Journal of Genetic Resources | ||
| دوره 8، شماره 2، آذر 2022، صفحه 255-263 اصل مقاله (301.04 K) | ||
| نوع مقاله: Research Article | ||
| شناسه دیجیتال (DOI): 10.22080/jgr.2022.23478.1312 | ||
| نویسندگان | ||
| Zahra Mohammadi Abgarmi1؛ Zohre Abdolvahabi* 2؛ Arash Moradi3؛ Bemanali Jalali Khanabadi4؛ Hafez Heydari5؛ Mohammadjafar Malek6؛ Shahla Mohammad Ganji3؛ Alireza Nourazarian7 | ||
| 1Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran | ||
| 2Metabolic Disease Research Center, Research Institute for Prevention Non-Communicable Diseases, Qazvin University Of Medical Sciences, Qazvin, Iran | ||
| 3Department of Molecular Medicine, Medical Biotechnology Institute, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran | ||
| 4Department of Clinical Biochemistry, Shahid Sadughi University of Medical Sciences, Yazd, Iran | ||
| 5Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran | ||
| 6Meli Bank Hospital, Tehran, Iran | ||
| 7Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran | ||
| تاریخ دریافت: 16 تیر 1401، تاریخ بازنگری: 08 شهریور 1401، تاریخ پذیرش: 14 شهریور 1401 | ||
| چکیده | ||
| Coronary Artery Disease (CAD) is the primary cause of mortality in developed and developing countries. Recently, oxidative stress has been reported to be associated with an increased incidence of atherosclerosis and cardiovascular disease. This study aims to investigate the levels of Vitamin C, Uric acid, bilirubin, and lipoprotein (a) (Lp (a)) in patients diagnosed with CAD and their relationship with Malondialdehyde (MDA) concentration. This study consists of 47 control subjects (28 women, 19 men) and 53 patients (15 women, 38 men) with CAD. Blood samples were collected after overnight fasting, and the sera were separated with low-speed centrifugation. MDA levels were determined through the TBARS method. Vitamin C and Lp (a) were determined through dinitrophenylhydrazine photometry and electro immunoassay (EID(, respectively. Total bilirubin and Uric Acid (UA) were determined immediately by routine laboratory methods. The mean serum MDA and Lp (a) levels were higher in patients with CAD compared to the control group (MDA: 0.89±0.41 µmol vs. 0.66± 0.24 µmol, p<0.05), Lp (a): 35±20 mg/ml, vs. 26.2±14.6 mg/ml, p=<0.05). However, no significant correlation was observed between the patients with Lp (a) in their serum MDA and the control group. The mean total bilirubin level was higher in the control group compared to the CAD patients (1.030 vs. 0.830, p<0.05). A significant inverse relationship existed between the patient's bilirubin, vitamin C levels, and MDA. Other differences and relations were insignificant. Also, there was no significant difference between the frequency of APOA1 -75 genotypes (G/G, G/A, A/A) in the CAD patients versus the control group (P>0.05). Finally, the elevated serum levels of MDA and Lp (a) were known to be independent risk factors for coronary heart disease. Also, there was a significant correlation between serum MDA levels and age, bilirubin, and vitamin C in patients with CAD. | ||
| کلیدواژه‌ها | ||
| Cardiovascular diseases؛ Coronary artery disease؛ Lipoprotein(a)؛ Oxidative stress | ||
| مراجع | ||
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