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اثر هشت هفته تمرین هوازی همراه با مکمل ویتامین E بر برخی نشانگرهای بیوژنز میتوکندری در بافت مغز موش‌های صحرایی مبتلا به پارکینسون | ||
| پژوهشنامه فیزیولوژی ورزشی کاربردی | ||
| مقاله 1، دوره 18، شماره 36، اسفند 1401، صفحه 15-27 اصل مقاله (553.46 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22080/jaep.2023.25731.2149 | ||
| نویسندگان | ||
| سعیده حجاریان* 1؛ عبدالعلی بنائی‌فر2؛ شهرام سهیلی3؛ سجاد ارشدی4 | ||
| 1دانشجوی دکتری فیزیولوژی ورزشی، دانشکده تربیت‌بدنی و علوم ورزشی، دانشگاه آزاد اسلامی واحد تهران جنوب، ایران | ||
| 2دانشیار گروه فیزیولوژی ورزشی، دانشکده تربیت‌بدنی و علوم ورزشی، دانشگاه آزاد اسلامی واحد تهران جنوب، ایران. | ||
| 3استادیار گروه فیزیولوژی ورزشی، دانشکده علوم انسانی، دانشگاه آزاد اسلامی واحد شهر قدس، ایران. | ||
| 4استادیار گروه فیزیولوژی ورزشی، دانشکده تربیت‌بدنی و علوم ورزشی، دانشگاه آزاد اسلامی واحد تهران جنوب، ایران. | ||
| تاریخ دریافت: 27 تیر 1402، تاریخ بازنگری: 16 شهریور 1402، تاریخ پذیرش: 28 شهریور 1402 | ||
| چکیده | ||
| اهداف: هدف از مطالعه حاضر بررسی اثر هشت هفته تمرین هوازی همراه با مکمل ویتامین E بر نشانگر بیوژنز میتوکندری سیرتوئین1(SIRT1) و گیرنده پروکسی زوم گاما فعال‌شده با کواکتیویتور آلفا (PGC-1α) در بافت مغز موش‌های صحرایی مبتلا به پارکینسون بود. روش مطالعه: در این مطالعه تجربی 40 سر موش صحرایی نر نژاد اسپراگ-داولی (سن 14-16 هفته و وزن 250 تا 270 گرم) پارکینسونی شده با رزرپین (mg/kg 2) به گروههای 1) رزرپین (Res)، 2) شم (Sh/حلال ویتامین E)، 3) تمرین هوازی (AT)، 4) ویتامین E (VE) و 5) ترکیب تمرین هوازی + ویتامین E (AT+VE) تقسیم شدند. جهت بررسی اثرات Res بر متغیرها تعداد 8 سر موش صحرایی نیز در گروه کنترل سالم (HC) قرار گرفتند. تمرین هوازی به مدت هشت هفته، پنج جلسه در هفته و هر جلسه مدت 15-48 دقیقه انجام شد. VE نیز روزانه mg/kg 30 به‌صورت خوراکی مصرف شد. یافته ها: مقادیر SIRT1 در گروههای AT (02/0=P)، VE (018/0=P) و AT+VE (001/0=P) به طور معنی‌داری بیشتر از گروه Res بود. همچنین این متغیر در گروه AT+VE به‌طور معنی‌داری بالاتر از گروههای AT (001/0=P) و VE (001/0=P) بود. همچنین مقادیر PGC-1α در گروههای AT (02/0=P)، VE (001/0=P) و AT+VE (001/0=P) به‌طور معنی‌داری بیشتر از گروه Res بود. همچنین این متغیر در گروه AT+VE به‌طور معنی‌داری بالاتر از گروههای AT (001/0=P) و VE (001/0=P) بود. نتیجه گیری: به نظر می‌رسد اگرچه تمرین هوازی و مکمل ویتامین E هرکدام به‌تنهایی بر نشانگرهای بیوژنز میتوکندریایی در بافت مغز متعاقب اختلالات نرودژنراتیو اثرگذار هستند؛ اما اثر تعاملی آن‌ها به‌مراتب مطلوب‌تر از اثر هرکدام به‌تنهایی است. | ||
| کلیدواژه‌ها | ||
| ویتامین E؛ بیماری پارکینسون؛ SIRT1 و PGC-1α | ||
| عنوان مقاله [English] | ||
| The effect of eight weeks aerobic training with vitamin E supplementation on some markers of mitochondrial biogenesis in the brain tissue of rats with Parkinson's disease | ||
| نویسندگان [English] | ||
| Saeedeh Hajarian1؛ Abdolali Banaeifar2؛ Shahram Soheili3؛ Sajjad Arshadi4 | ||
| 1Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Islamic Azad University, South Tehran Branch, Iran. | ||
| 2Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Islamic Azad University, South Tehran Branch, Iran. | ||
| 3Department of Exercise Physiology, Faculty of Humanities, Islamic Azad University, Quds Branch, Iran. | ||
| 4Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Islamic Azad University, South Tehran Branch, Iran. | ||
| چکیده [English] | ||
| Objectives: The aim of this study was to investigate the effect of eight weeks of aerobic training with vitamin E supplementation on the mitochondrial biogenesis marker sirtuin 1 (SIRT1) and peroxisome gamma receptor activated with coactivator alpha (PGC-1α) in the brain tissue of rats with Parkinson's disease. Methods: In this experimental study, 40 Sprague-Dawley male rats (age 14-16 weeks and weight 250-270 grams) were given Parkinsonism with reserpine (2 mg/kg) were divided into groups (1) Res, (2) sham (Sh/soluble vitamin E), (3) AT, (4) VE and (5) AT+VE. In order to investigate the effects of Res on the variables, 8 rats were included in the healthy control group (HC). Aerobic training was done for eight weeks, five sessions per week and each session lasted 15-48 minutes. VE was also taken orally at 30 mg/kg daily. Results: SIRT1 and PGC-1α mRNA values in AT, VE and AT+VE groups were significantly higher than Res group (P≤0.05). In addition, SIRT1 and PGC-1α values in the AT+VE group were significantly higher than the AT and VE groups (P≤0.05). SIRT1 mRNA values in AT (P=0.02), VE (P=0.018) and AT+VE (P=0.001) groups were significantly higher than Res group. It was also significantly higher in AT+VE group than AT (P=0.001) and VE (P=0.001) groups. Also, PGC-1α mRNA values in AT (P=0.02), VE (P=0.001) and AT+VE (P=0.001) groups were significantly higher than Res group. It was also significantly higher in AT+VE group than AT (P=0.001) and VE (P=0.001) groups. Conclusion: It seems that although aerobic training and vitamin E supplementation alone have an effect on mitochondrial biogenesis markers in brain tissue following neurodegenerative disorders; but their interactive effect is much more favorable than the effect of each of them alone. | ||
| کلیدواژه‌ها [English] | ||
| Vitamin E, Parkinson's disease, SIRT1 and PGC-1α | ||
| مراجع | ||
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