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Sheibani, Ali, Shishehbore, M. Reza, Vafaie-Shahi, Shohrah. (1392). Application of Ion Mobility Spectrometry for Determination of Morphine in Human Urine. پژوهشنامه مدیریت اجرایی, 2(1), 59-64.
Ali Sheibani; M. Reza Shishehbore; Shohrah Vafaie-Shahi. "Application of Ion Mobility Spectrometry for Determination of Morphine in Human Urine". پژوهشنامه مدیریت اجرایی, 2, 1, 1392, 59-64.
Sheibani, Ali, Shishehbore, M. Reza, Vafaie-Shahi, Shohrah. (1392). 'Application of Ion Mobility Spectrometry for Determination of Morphine in Human Urine', پژوهشنامه مدیریت اجرایی, 2(1), pp. 59-64.
Sheibani, Ali, Shishehbore, M. Reza, Vafaie-Shahi, Shohrah. Application of Ion Mobility Spectrometry for Determination of Morphine in Human Urine. پژوهشنامه مدیریت اجرایی, 1392; 2(1): 59-64.

Application of Ion Mobility Spectrometry for Determination of Morphine in Human Urine

Caspian Journal of Chemistry
مقاله 7، دوره 2، شماره 1، دی 2013، صفحه 59-64    اصل مقاله (110.03 K)
نوع مقاله: Review paper
نویسندگان
Ali Sheibani* ؛ M. Reza Shishehbore؛ Shohrah Vafaie-Shahi
Department of Chemistry, Yazd Branch, Islamic Azad University, Yazd, Iran
تاریخ دریافت: 13 مهر 1392،  تاریخ پذیرش: 13 مهر 1392 
چکیده
In this study, a rapid, simple and sensitive ion mobility spectrometry (IMS) method with corona discharge as ionization source was described for the morphine determination in human urine. Morphine was extracted and purified from urine samples using solid phase extraction procedure with C18 column. It can offer the clean extracts which no extra peaks were observed in IMS. Under operating experimental conditions (Temperature; injection: 220 and oven: 180 oC, Flow rate; carrier: 300 and drift: 600 mL min-1,Voltage;corona: 2200 and drift: 6700 V), developed method showed good linearity in the ranges of 0.44 to 6.91 and 6.91 to 22 ng mL-1 with correlation coefficients (R2) of 0.9979 and 0.9966, respectively. The limit of detection was 0.1 ng mL-1, and precision as relative standard deviation was 11%. The capability of the proposed method was evaluated by the analysis of human urine as a real sample that satisfactory results were obtained.
کلیدواژه‌ها
Ion mobility spectrometry (IMS)؛ Morphine؛ Human urine؛ Corona discharge
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